Had a lot of fun writing this “tools of the trade” highlight for our Variant-EFFECTS technology. Check it out! 🛠️
Michael Montgomery
New online! Measuring the effects of regulatory variants in an endogenous context
Nature Reviews Genetics, Published online: 11 June 2025; doi:10.1038/s41576-025-00863-wIn this Tools of the Trade article, Michael Montgomery presents Variant-EFFECTS, a high-throughput and generalizable approach that combines prime editing, flow cytometry, sequencing, and computational analysis to quantify the effects of regulatory variants.
