Very cool work! I'm particularly excited about the integration of multiple models/prediction heads in this approach, given how many aspects of gene regulation likely need to be considered to achieve a specific quantitative design goal.
Michael Montgomery
Our preprint on designing and editing cis-regulatory elements using Ledidi is out! Ledidi turns *any* ML model (or set of models) into a designer of edits to DNA sequences that induce desired characteristics.
Preprint: www.biorxiv.org/content/10.1...
GitHub: github.com/jmschrei/led...
The development of modern genome editing tools has enabled researchers to make such edits with high precision but has left unsolved the problem of designing these edits. As a solution, we propose Ledi...
