The function of nuclear speckles is revealed! This is an incredibly important paper with absolutely beautiful data! Wow! www.cell.com/cell/fulltex...
I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.
Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich
regions. This work shows that the evolution and expansion of core speckle proteins
were crucial for the increase...
Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...
On July 1st, I'll be joining the faculty at UC Berkeley, with a joint appointment in the Division of Molecular Therapeutics within MCB and the Helen Wills Neuroscience Institute.
Thrilled to see our Deep-Phase paper now online in
@cellcellpress.bsky.social! 🎉 The final version expands Deep-Phase across labeling modalities, adds dual-condensate imaging to dissect pathway specificity, and shows greater robustness to batch effects than classical image-analysis methods.
Congrats Lindsay. The skies are bluer in Texas!
So excited that UTSW was able to retain your talent. Mol Bio SLAYS!
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
Yay @anitadonlic.bsky.social !!!
Missed this sadly. Jordy is a rock star! Cool work!
CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...
A deep learning method quantitatively decodes nucleolar, nuclear speckle, and viral
condensate morphology to reveal underlying biochemical states. Applying this framework
reveals a previously unrecogn...
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
Thrilled to share that I’ll be starting my lab as an Assistant Professor and Endowed Scholar in the UT Southwestern Molecular Biology Dept this Fall! 🥳 We’ll study #peroxisomes #mitochondria #metabolism via the lens of neonatology 👶🏻, a very exciting frontier in medicine! #neotwitter
www.cell.com/cell/fulltex...
Tugce Aktas
Check out our newest paper from the great @jbotello.bsky.social . Such an awesome discovery that the ribosome population undergoes molecular aging!!!!
