Pramipexole significantly alleviates anhedonia in mood disorders, showing robust efficacy and tolerable safety as an adjunctive therapy.
by Ventorp F, Asp M (...) Lindqvist D et 20 al. in Nat Med #MedSky
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Loss of STMP1 disrupts mitochondrial structure, fueling inflammation and accelerating heart failure in aging cardiomyocytes.
by Ruberto FP, Lee CJM (...) Foo RSY et 22 al. in Circulation #MedSky
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Low-Dose Rivaroxaban Fails to Lower Cardiovascular Events in Advanced CKD While Increasing Major Bleeding Risks in Patients.
by Badve SV, Perkovic V (...) Gallagher M et 34 al. in JAMA #MedSky
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Sodium bicarbonate fails to reduce major kidney events in critically ill patients with metabolic acidosis on vasopressors.
by None None, Serpa Neto A (...) Udy A et 26 al. in N Engl J Med #MedSky
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Carbocisteine and hypertonic saline donβt shorten mechanical ventilation duration in acute respiratory failure and pose significant risks.
by Connolly B, Dickson N (...) McAuley DF et 30 al. in N Engl J Med #MedSky
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Microglial state transitions at the AΞ²-tau interface reveal distinct resilience mechanisms in aging, offering insights for potential Alzheimer's therapies.
by Lu A, Chen WT (...) De Strooper B et 23 al. in Nat Med #MedSky
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New obesity subphenotype with fast gastric emptying and low GLP-1 levels shown to respond better to tirzepatide therapy.
by Ticho AL, McRae AN (...) Acosta AJ et 12 al. in Gastroenterology #MedSky
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Tirofiban enhances recovery odds by 22% in acute ischemic stroke patients not responding to tenecteplase, with minimal bleeding risk.
by None None, Liu X (...) Zeng G et 61 al. in JAMA #MedSky
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Early vasopressors and fluid restriction in septic shock yield no difference in hospital days compared to fluid-heavy approaches.
by None None, Peake SL (...) Bellomo R et 16 al. in N Engl J Med #MedSky
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