From the experience of @stitches.today, we bring you the best papers in medicine, daily in your inbox - for free!
Subscribe 👉 www.stitches.today/medicine
Loading...
Tirofiban enhances recovery odds by 22% in acute ischemic stroke patients not responding to tenecteplase, with minimal bleeding risk.
by None None, Liu X (...) Zeng G et 61 al. in JAMA #MedSky
👉 get more here
📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2848809
Sodium bicarbonate fails to reduce major kidney events in critically ill patients with metabolic acidosis on vasopressors.
by None None, Serpa Neto A (...) Udy A et 26 al. in N Engl J Med #MedSky
👉 get more here
📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2600526
Early vasopressors and fluid restriction in septic shock yield no difference in hospital days compared to fluid-heavy approaches.
by None None, Peake SL (...) Bellomo R et 16 al. in N Engl J Med #MedSky
👉 get more here
📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2516225
Low-Dose Rivaroxaban Fails to Lower Cardiovascular Events in Advanced CKD While Increasing Major Bleeding Risks in Patients.
by Badve SV, Perkovic V (...) Gallagher M et 34 al. in JAMA #MedSky
👉 get more here
📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2850100
All-oral Revumenib, Decitabine, and Venetoclax combo achieves high response rates and durable remissions in tough-to-treat AML patients.
by Issa GC, Cuglievan B (...) Kantarjian HM et 29 al. in J Clin Oncol #MedSky
👉 get more here
📖 read the article: https://ascopubs.org/doi/10.1200/JCO-26-01159
Loss of STMP1 disrupts mitochondrial structure, fueling inflammation and accelerating heart failure in aging cardiomyocytes.
by Ruberto FP, Lee CJM (...) Foo RSY et 22 al. in Circulation #MedSky
👉 get more here
📖 read the article: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.073677
Carbocisteine and hypertonic saline don’t shorten mechanical ventilation duration in acute respiratory failure and pose significant risks.
by Connolly B, Dickson N (...) McAuley DF et 30 al. in N Engl J Med #MedSky
👉 get more here
📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2603406
Pramipexole significantly alleviates anhedonia in mood disorders, showing robust efficacy and tolerable safety as an adjunctive therapy.
by Ventorp F, Asp M (...) Lindqvist D et 20 al. in Nat Med #MedSky
👉 get more here
📖 read the article:
New obesity subphenotype with fast gastric emptying and low GLP-1 levels shown to respond better to tirzepatide therapy.
by Ticho AL, McRae AN (...) Acosta AJ et 12 al. in Gastroenterology #MedSky
👉 get more here
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0016508526069428
Microglial state transitions at the Aβ-tau interface reveal distinct resilience mechanisms in aging, offering insights for potential Alzheimer's therapies.
by Lu A, Chen WT (...) De Strooper B et 23 al. in Nat Med #MedSky
👉 get more here
📖 read the article:
Pramipexole, in patients with major depressive disorder, dysthymia or bipolar depression, reduced Snaith−Hamilton Pleasure Scale scores significantly compared to placebo.
