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studying genetic and environmental contributions to cell fitness in cancer and immunity | biology-engineering-biotechnology | #HPLM | current: investigator @Morgridge_Inst, assistant prof @UW-Madison
Jason Cantor
1/12 🛣️ Mapping nitrogen metabolism has lagged carbon due to substrate diversity. In @natmetabolism.nature.com, we introduce a platform to do this mapping at scale and identify mechanisms by which differentiation state dictates pyrimidine synthesis. 🧵👇 🔗 www.nature.com/articles/s42...
1mo
Milan Savani
Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
2mo
Lucas Sullivan
2mo
Nature Metabolism
Nature Metabolism, Published online: 07 April 2026; doi:10.1038/s42255-026-01499-8Previously uncharacterized cysteine-derived conjugates, including with endogenous sugar metabolites, accumulate in cancer cells with constitutive NRF2 activation and account for some of the increased cystine uptake that cannot be explained by conventional cysteine metabolism.
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Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells