The story of how multiple RBPs cooperate to repress translation is now out in @cp-cellreports.bsky.social by @marcopayr.bsky.social and in a great collaboration with @hennig-lab.bsky.social!
www.cell.com/cell-reports...
Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg!
Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
Using #SingleMolecule imaging we find that TFs:
-boost co-transcriptional #ribosomal #RNA processing!
-their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)!
@biorxivpreprint.bsky.social Anastasiia Chaban @embl.org
www.biorxiv.org/content/10.6...
Yi-Wei Chang
Olivier Duss
Olivier Duss
My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances!
He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding.
See more details in EMBL post below!
Ever wondered how several individual RBPs cooperate to repress translation?
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
Thinking Like a Scientist, Part Two: The Omics Illusion network.febs.org/posts/thinki... #FEBSnet
Olivier Duss
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection!
www.nature.com/articles/s41...
Excellent work from Tatyana Shelkovnikova Lab in @natcellbio.nature.com in collaboration @embl.org
Video
Olivier Duss
Olivier Duss
Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...
Travel’s got me wiped, but catching up with @colindascheele.bsky.social, @pierresantucci.bsky.social & @olivierduss.bsky.social at #FEBS2025 made it totally worth it. Huge thanks to Pelin Telkoparan and Dilek Cevik for the wonderful hospitality—what a time in Istanbul!
Olivier Duss
Olivier Duss
Olivier Duss
In a collaboration between the @hennig-lab.bsky.social and @olivierduss.bsky.social labs we revealed how proteins work together to control gene expression through mRNA translation repression! Using single-molecule microscopy, we watched individual molecules in action. doi.org/10.1101/2025... 🧵
Video
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
Marco Payr
Come discuss recent breakthroughs in RNA biology, from molecules to organisms, at the EMBO | EMBL Symposium 'The complex life of RNA'! 👉 s.embl.org/ees26-12-bl
Submit your abstract by 7 July and present your research at #EESRNA 🥼
EMBL
Silvia Ramundo
EMBL Events
(1/2) EMBL researchers led by @olivierduss.bsky.social have developed a microscopy technique that enables them to observe individual RNA molecules being produced and folding into different shapes.
Learn more: www.science.org/doi/10.1126/...
