Professor @ Hebrew University | Neurodevelopmental disorders | Chromatin regulators in brain development and function
https://neurogenetics.huji.ac.il
Sagiv Shifman
Loading...
Congratulations to Alana Amelan on the Muchrik 2025 PhD award and a great talk!
Paper: “CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment” (Nat Neurosci).nature.com/articles/s4159…)
Nature research paper: Biological insights into schizophrenia from ancestrally diverse populations
go.nature.com/4pMhb7f
Nature
Sagiv Shifman
Why do pathogenic variants in the same gene lead to different neurodevelopmental outcomes?
Our Trends in Genetics review discusses how variant effects, genetic background, environment, and developmental noise may all contribute.
www.cell.com/trends/genet...
authors.elsevier.com/a/1mxFv_3rsx...
New preprint on technologies to scale up CRISPR screens.
We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.
We also introduce an approach for cloning lentiviral libraries with billions of elements.
With the advent of sequencing technologies in recent years, hundreds of high-confidence
risk genes have been implicated in neurodevelopmental disorders (NDDs). However, individuals
carrying pathogenic...
Hot off the press, our latest publication on the functional role of gene body methylation (gBM).
academic.oup.com/nar/article/...
Work spearheaded by Jakub Zastapilo with help from @robynemm.bsky.social and Liudmila Mikheeva and co-led by Marco Catoni and @ubechtold.bsky.social 1/3
Now final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social
Enjoy 👇👇 www.cell.com/molecular-ce...
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Sagiv Shifman
Many living people carry fragments of Neanderthal DNA, remnants of ancient interbreeding events, with uneven distribution across chromosomes. New work by @sarahtishkoff.bsky.social lab suggests patterns are most consistent with Neanderthal contribution to human populations being highly male biased.🧪
Thomas Norman
Genome-wide association studies incorporating data for populations of African ancestry provide an expanded view of the genetic basis of schizophrenia, which has previously been studied mainly in European and East Asian cohorts.
Abstract. Non-genetic variability in gene expression is an inevitable consequence of the stochastic nature of processes driving transcription and translati
academic.oup.com
Simon Fisher
Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2),
propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro.
These effects can translate in vivo...
Sex biases in admixture and other demographic processes are recurrent features throughout human evolution. For admixture between Neanderthals and anatomically modern humans (AMHs), sex bias has been p...
