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Now final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social Enjoy 👇👇 www.cell.com/molecular-ce...
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www.cell.com
Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2), propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro. These effects can translate in vivo...
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Rob Schneider