the budweiser logo is a cyclohexane chair #chemsky
"Right now, in some underfunded lab, a scientist is chasing a question that sounds pointless...a century of experience says that funding people to do this work is a good bet. If we stop making that bet, we will pay for it in cures no one will know to miss."
In 1960, 67% of stereocenters in FDA drugs were S. By 2025: 53%. A 65-year erasure of biosynthetic bias by synthetic chemistry — written in R and S. (n=1,212 drugs, RDKit)
can you not buy NP-40 detergent anymore?
"...there are also broad prohibitions against any use of federal funds for collaboration with a whole list of countries, starting with China. Any use at all – paper publication charges, travel, reagents, doesn’t matter."
Yikes! The continued dismantling of US science...
#Chemsky 🧪
A subset of CysDB fragments occupies chemical space with no overlap with approved drugs — likely flat, aromatic, low-complexity chemotypes underrepresented in drug space. The overlapping subset probes cysteine sites with drug-like physicochemistry.
sculpturatus.com/surveyorchemscape
Half of FDA-approved drugs are achiral. Of the chiral half, R/S splits 53/47 favoring S — statistically real, but barely. Natural product biosynthetic bias, slowly erased by synthetic chemistry. (n=1,217, RDKit)