π New Study: Scientists working on a Gut Cell Atlas have conducted #singlecell #RNAseq on intestinal cells, discovering clusters of immune and endothelial cells localise around scar tissue in the submucosa. π§¬π»
β‘οΈ buff.ly/0Y9bpZN
@uoe-igc.bsky.social @helmsleytrust.bsky.social
#CellAtlas #scRNAseq
π Course: Advanced Python for Data Science & Bioinformatics
π 23β26 March | π Online
Ready to level up your Python skills for biology? Dive into data wrangling, BioPython, visualization & machine learning, and build an end-to-end project πππ§¬
www.physalia-courses.org/courses-work...
#Python
Excited to share our work published in @cp-immunity.bsky.social! We investigated the role of HIF-1Ξ± in CD4 T cells using #Xenium spatial transcriptomics in infected lungs containing #TertiaryLymphoidStructures (TLS) (1/10).
www.cell.com/immunity/ful...
As scRNA-seq cohorts grow in scale (e.g. FinnGen, TenK10K), so does the need for methods that can handle millions of cells from thousands of donors. LIVI's scalable design enables systematic trans-eQTL discovery in such datasets, revealing cellular mechanisms underlying complex disease risk. 11/n
Working on trans-eQTL mapping with population-scale scRNA-seq? Meet LIVI, our latest framework that enables efficient trans-eQTL mapping at single-cell resolution across cohorts of hundreds to thousands of donors.
Preprint: doi.org/10.64898/202...
Summary in the 𧡠below by @danaivagiaki.bsky.social
Allele-specific splicing modulates protein isoforms and Alzheimer's risk https://www.biorxiv.org/content/10.64898/2026.02.13.705796v1
A minimal PyTorch re-implementation of AlphaFold2
github.com/ChrisHayduk/...
We need more stuff like this. The incentive is to always be making the new groundbreaking tool, while maintenance + improvement of "old" tools gets left behind. But there is still heaps to be gained in "old" tools
The process of #PeerReview is vital to contemporary science, but is also under enormous strain. @carlbergstrom.com & Kevin Gross use mathematical models to dissect the threats to the long-term viability of peer review, suggesting ways to stabilize it @plosbiology.org π§ͺ plos.io/4kR02bo