Online now: A longitudinal atlas of human psoriatic skin reveals the mechanisms of anti-IL-23 therapy in disrupting the type 17 inflammatory circuit
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Patients with psoriasis show a durable clinical response to the anti-IL-23 biologic, risankizumab, even after treatment cessation. Here, Jiang et al. generate a longitudinal single-cell and spatial transcriptomics atlas of patients pre- and post-treatment. They reveal reduced CD8+ tissue-resident memory T cell expansion, diminished inflammatory dendritic cells, and decreased APOE+/IL34+ fibroblasts associated with lasting amelioration of psoriatic inflammation.
