RPA, long known for its role in DNA replication and repair, is now shown to boost telomerase activity!
Big congrats to @cijilim.bsky.social's lab for this milestone achievement!
Glad our lab (via Michael O’Connor) could contribute to this collaboration!
Xuhui Huang
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
