🔬 Assistant Research Professor @ IU School of Medicine | Division of Clinical Pharmacology
I am a bioinformatician specializing in snRNA-seq, scATAC-seq, and DNA methylation analysis to understand biomolecular changes during DDI trials.
Debora Gisch
Proud to share that our human clinical trial on CBD and immune function is now published!
Led by Dr. Michael Eadon (Clinical Pharmacology Division, Indiana University School of Medicine) and honored to contribute as author.
This is the 5th paper from this clinical trial.
Last day at Kidney Week! Thank you for all the opportunities to learn and exchange experiences! #KidneyWk San Diego, CA 2024
Hope to see you all next year in Houston, TX!"
What does CBD really do to the immune system in humans?
🧬 We gave healthy adults oral cannabidiol oil.
📉 Lymphocyte proliferation dropped.
🔥 Inflammatory signals shifted.
💡 T effector memory cells expanded.
Preprint out now:
🔗 www.biorxiv.org/content/10.1...
#CBD #scRNAseq #Immunology #pk
🚨 Preprint Alert! 🚨
We’re thrilled to share our long-awaited #Atlas 2.0 manuscript:
“Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney” is now live on bioRxiv!
📄 Read the full preprint: www.biorxiv.org/content/10.1...
📑 Need something to read this weekend? If so, you're in luck!
"Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules" fueled by #KPMP investigators is hot off the press today @science.org
www.science.org/doi/10.1126/...
A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1
Atlases galore: where to next
🧪
www.nature.com/articles/s41...
Cannabidiol is widely available and often used for pain management. Individuals with kidney disease or renal allografts have limited analgesia options. We conducted a Phase 1 human study to compare th...
Are you an artist inspired by the world of biology? The Science Museum in London is inviting proposals for an art commission that will explore and showcase the themes raised by the Human Cell Atlas. Find out more:
The interplay in expression of the stem cell markers THY1 and PROM1 in kidney proximal tubules marks the timeline of disease.
Hundreds of researchers collaborate on maps of the human body and the subcellular realm. As they scout out their next mapping expeditions, they take stock of atlas-making.
www.nature.com
Kidney Precision Medicine Project
Kidney Precision Medicine Project
Cannabidiol is used off-label for chronic pain, yet little is known about its immune system effects in transplant recipients.
Here, ASCI member Gisch et al. report CBD exerts anti-inflammatory effects but maintains T effector memory cell differentiation in humans: doi.org/10.1172/jci....
Introduction : Tomorrow: The Bennett Gallery will be the Science Museum's new landmark gallery expl... A Tender Notice by Science Museum Group. Value £0-£100K.
