Inlay

Flavivirus infectivity in mosquitoes like Aedes aegypti is shaped by mosquito-capsid interactions, shedding light on species-specific vector traits. PMID:41639463, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10100-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Multiple mosquito species serve as competent vectors to carry and transmit numerous flaviviruses1,2. Several long-standing scientific questions remain to be answered, including identification of the fundamental factors that facilitate flavivirus infectivity in mosquitoes and the genetic basis that contributes to the naturally occurring interspecies specificity of mosquitoes to flaviviruses3–8, such as Aedes aegypti mosquitoes to dengue virus (DENV). Here we report that circulating mature virions are inactivated by the acidity of mosquito haemolymph; thus, extracellular vesicles carrying replication-competent viral nucleocapsids serve as the predominant means of intercellular viral dissemination. Mechanistically, mosquito valosin-containing protein (VCP) binds to the viral capsid, thereby allowing the incorporation of nucleocapsids into extracellular vesicles. The capsid of a flavivirus (such as DENV) selectively binds to the VCP of its natural vector (Ae. aegypti), but not to that of a

At last! Please check out our study now published @natcomms.nature.com on the #virus small #RNAs profiles across Aedes aegypti #mosquitoes from labs and around the world: www.nature.com/articles/s41...

This study is a small RNA genomics survey from global Aedes aegypti mosquito samples, and detected replicating viruses. This study then isolated several mosquito viruses into cell cultures to show tha...

A new blood test may improve the mapping of mosquito-borne diseases like dengue, Zika and chikungunya, which are spreading to new regions as temperatures rise. Study from KI and @pasteur.fr published in @natcomms.nature.com today by @vyman.bsky.social et al 🧪 #GlobalHealth news.ki.se/new-blood-te...

🦟 🦠 Notre équipe du laboratoire "Génomique Évolutive, Modélisation et Santé" (GEMS) @cnrsecologie.bsky.social @pasteur.fr a identifié un gène clé impliqué dans la sensibilité du #moustique Aedes aegypti au #virus de la #dengue www.inee.cnrs.fr/fr/cnrsinfo/...

🚨 We're hiring! A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

🦟 🦠 Notre équipe et celle de @simonlorierelab.bsky.social au sein du laboratoire "Génomique Évolutive, Modélisation et Santé" (GEMS) @cnrsecologie.bsky.social @pasteur.fr avons élucidé les déterminants génétiques viraux de la transmissibilité du #virus #Zika par le #moustique Aedes aegypti

Two postdoc positions for a number of exciting epidemic modelling projects opening in my Unit at @pasteur.fr in beautiful Paris. Deadline for applications: 13th April. More details at the following link: research.pasteur.fr/job/two-post...

The Insect-Virus Interactions Unit is looking for a postdoctoral researcher to investigate the genomic variations underlying a mosquito’s capacity to transmit human arboviruses. Description Our resear...

🚨 A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

Job description We are recruiting 2 postdocs to contribute to research projects in the Mathematical Modelling of Infectious Diseases Unit, at Institut Pasteur in Paris. The postdocs will develop state...

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

#RésultatScientifique🔎 Une étude publiée dans Nature Communications analysent pourquoi les moustiques transmettent plus efficacement les souches africaines du virus Zika que les souches asiatiques. ➡️ www.inee.cnrs.fr/fr/cnrsinfo/...