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Delighted to see this out! Human embryos depend on FGF/ERK signalling to specify epiblast versus primitive endoderm cells. Well done Claire Simon and the lab for their contributions! Many thanks to Mary Herbert @josh-brickman.bsky.social @cwhanna.bsky.social labs for brilliant contributions!
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Nature Communications - The authors show human embryo lineage specification in the blastocyst is driven by differential FGF/ERK signaling, which segregates yolk sac-fated hypoblast and embryonic...
rdcu.be
Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst
Niakan Lab