Our group investigates the function of genes regulating early human development and molecular mechanisms directing cell fate in human embryos. Posts from any member of the lab.
Check out our website: https://niakanlab.com
Niakan Lab
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This is an excellent news and views article from Corentin Mollier & Jean-Lรฉon Maรฎtre @maitrejl.bsky.social
www.nature.com/articles/s41...
Recently was Qiulinโs viva and he passed without corrections! We are so proud of all the hard work and dedication that led to this achievement! Thanks so much to everybody that joined the celebration!
Thrilled to see this published!
Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated.
Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
Really exciting to see our new review published!
This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology.
Check it out here: doi.org/10.1242/dev....
A human embryo implantation model from the @Rugg-Gunn Lab
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! Itโs been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors ๐ฅ๐พ
www.cell.com/cell/fulltex...
Very excited to share our newest findings! A very long team effort pursued by multiple team members -to frantically reproduce everything over and over-, we show mTOR-Polycomb synergy at promoters of developmental master regulator TFs in ESCs prior to their expression. www.biorxiv.org/content/10.6...
Looking to pursue cutting-edge research in early development, maternal-fetal interaction, or placental biology? See ๐
- Funded PhD www.trophoblast.cam.ac.uk/phd-students...
- Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat...
- MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
Summary: This Review examines the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering ...
Building an in vitro model of receptive endometrium allows investigation of human
embryo implantation and early post-implantation development and recapitulates the
earliest stages in establishing the ...
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Carter Lab
An optimized approach for live imaging of human embryos enables visualization of mitotic errors during blastocyst development.
www.nature.com
Dosage compensation of sex chromosomes through X-chromosome inactivation (XCI) is required for mice extra-embryonic tissue growth and embryo development. The species specificity in mechanisms and timi...
Learn more about this research in our interview with Peter Rugg-Gunn ๐งช
youtu.be/2NYsWPp1UYk?...
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8
