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Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
Recently was Qiulin’s viva and he passed without corrections! We are so proud of all the hard work and dedication that led to this achievement! Thanks so much to everybody that joined the celebration!
Thrilled to see this published! Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated. Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
7mo
2mo
3d
This is an excellent news and views article from Corentin Mollier & Jean-Léon Maître @maitrejl.bsky.social www.nature.com/articles/s41...
Video
7mo
Really exciting to see our new review published! This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology. Check it out here: doi.org/10.1242/dev....
1mo
An optimized approach for live imaging of human embryos enables visualization of mitotic errors during blastocyst development.
www.nature.com
Long-term imaging of cell divisions in human preimplantation embryos - Nature Biotechnology
Summary: This Review examines the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering ...
doi.org
The vertebrate yolk sac: evolutionary origins and current advances in in vitro models
Niakan Lab
Niakan Lab
Niakan Lab
Niakan Lab
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8
7mo
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Carter Lab
8mo
Very excited to share our newest findings! A very long team effort pursued by multiple team members -to frantically reproduce everything over and over-, we show mTOR-Polycomb synergy at promoters of developmental master regulator TFs in ESCs prior to their expression. www.biorxiv.org/content/10.6...
𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐚𝐥𝐞𝐫𝐭! 🎉 “𝐗𝐈𝐒𝐓 𝐃𝐫𝐢𝐯𝐞𝐬 𝐗-𝐂𝐡𝐫𝐨𝐦𝐨𝐬𝐨𝐦𝐞 𝐈𝐧𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐒𝐚𝐟𝐞𝐠𝐮𝐚𝐫𝐝𝐬 𝐅𝐞𝐦𝐚𝐥𝐞 𝐄𝐱𝐭𝐫𝐚𝐞𝐦𝐛𝐫𝐲𝐨𝐧𝐢𝐜 𝐂𝐞𝐥𝐥𝐬 𝐢𝐧 𝐇𝐮𝐦𝐚𝐧𝐬” 𝐢𝐬 𝐧𝐨𝐰 𝐨𝐧 𝐛𝐢𝐨𝐑𝐱𝐢𝐯! www.biorxiv.org/content/10.1...
A method to label cultured human embryos finds chromosome segregation errors in placenta-fated cells.
go.nature.com
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - Nature Biotechnology
1mo
6mo
Nature Biotechnology
Looking to pursue cutting-edge research in early development, maternal-fetal interaction, or placental biology? See 👇 - Funded PhD www.trophoblast.cam.ac.uk/phd-students... - Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat... - MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...
www.biorxiv.org
8mo
Dosage compensation of sex chromosomes through X-chromosome inactivation (XCI) is required for mice extra-embryonic tissue growth and embryo development. The species specificity in mechanisms and timi...
www.biorxiv.org
XIST Drives X-Chromosome Inactivation and Safeguards Female Extraembryonic Cells in Humans
Rob Klose
Aydan Bulut-Karslioglu
Vincent Pasque
The Loke Centre for Trophoblast Research
A human embryo implantation model from the @Rugg-Gunn Lab *key for understanding the early extraembryonic-maternal interactions Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾 www.cell.com/cell/fulltex...
5mo
Building an in vitro model of receptive endometrium allows investigation of human embryo implantation and early post-implantation development and recapitulates the earliest stages in establishing the ...
www.cell.com
Modeling human embryo implantation in vitro
Teresa Rayon
Learn more about this research in our interview with Peter Rugg-Gunn 🧪 youtu.be/2NYsWPp1UYk?...
5mo
YouTube video by Babraham Institute
youtu.be
Breaking new ground in understanding embryo implantation in early development
Babraham Institute