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BIGSMALL is now implemented in SPACEtomo. Setup is easy: - define low mag parameters with SerialEM Search preset - add LM + HM targets in the same beam-shift group - acquire! (5/6)
1mo
New work from my team: pubs.acs.org/doi/10.1021/... We used probes to ID targets of carbapenems in M. abscessus. 17 targets active in both carbon starved and replicating cultures. Includes validation of 9 targets. Part of a special issue ("NTM Pathogens – Biology, Infection, and Drug Discovery).
16d
Very excited about our new work highlighting the role of lipids in mediating multi-channel assemblies of Cx-46/50!
1mo
BTW, this tutorial includes a bit of Mosaic, a membrane modeling software from the Kosinski lab a lot of tomo labs may have missed, but which I absolutely love!
3d
My day of the class used the 2.0.0beta1 release of surface morphometrics, which is packed full of a TON of new features, and is 40-50x faster than the 1.0 release. Expect a manuscript later this summer!
Kvelling (reverse kvelling?) for my mom today!
The pathogen Mycobacterium abscessus (Mab) can cause severe and difficult-to-treat chronic lung infections. Despite the rising incidence and clinical concern of Mab infections, treatment options are l...
Chemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessus
pubs.acs.org