#scientist #mom interested in #DNA repair #mouse genetics #hematopoiesis #immunodeficiency #lymphoma, and #leukemia. opinions are my own.
Zha Lab
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Why do mammalian cells need PAR, PARP1/2, but yeast does NOT? While studying the impact of PARG inhibition, Isaac in the lab found that extra-PAR sequesters nuclear PAR-binding proteins (XRCC1 and its partners, etc.) into nuclear condensates. biorxiv.org/content/10.6...
Zha Lab
Unfortunately, due to unforeseen reasons, Social DNAing will be canceled today!
Thank you, Dr. Zhang, for a great talk. Dr. Yi from UCLA will take us to examine the hidden rearrangements - SCE in cancer genomes and, surprisingly, in normal cells as well. Sign up www.cancer.columbia.edu/research/pro...
Our new review on NHEJ just came out on G&D genesdev.cshlp.org/cgi/content/... Highlight the 5 phases, and importantly, the 5 protein bridges that bring the 2 DNA ends together for NHEJ. Thank Dr. Geunil Yi, for generating the illustration for all structural models.
Thank Dr. Kunkle, for a really thorough talk on DNA replication polymerases. This week Dr. Olsen will help us understand RAD51. Sign up at www.cancer.columbia.edu/research/pro...
Dr. Thomas Kunkel will visit Social DNAing this week. Sign up and tune in! www.cancer.columbia.edu/research/pro...
Drs. Zhu and Jiang in the Zha lab developed FISH probes for murine rDNA (on Addgene:240559), uncovered high somatic and germline heterogeneities in inbred mice, and unique roles of ATM/LIG4/BRCA1 at rDNA, and proposed a model for single-ended DSB at rDNA loci. academic.oup.com/nar/article/...
This week Dr. Doksani will join Social DNAing to discuss telomere biology! Please note the US is now in summer saving time. Check you local time! www.cancer.columbia.edu/research/pro...
Are you ready for the Summer? Social DNAing is! Check out the 2026 Summer line-up! Please note one schedule change on June 4th, 2026. Please RT! Sign up at cancer.columbia.edu/research/pro...
Thank Ylli for a wonderful view on telomere. This week, we have another telomere expert visit - Dr. Lottersberger will discuss the role of DNA-PKcs at telomere. Sign up at www.cancer.columbia.edu/research/pro...
