Senior scientist @Princess Margaret Cancer Centre, Prof @UofT. BHAG: Conquer cancer by treating it as a disease of the chromatin. https://lupienlab.uhnresearch.ca/
Loading...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Upcoming cancer epigenetics conference in Paris (Oct 13-16, 2026). Consider registering: www.atoutcom.com/cancer-epige...
Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome.
Grateful to the team & collaborators. www.nature.com/articles/s41...
Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness.
We found that transposable elements sustain stem-like states in AML and predict patient outcomes.
www.nature.com/articles/s41...
www.lalsace.fr/science-et-t...
Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome.
Grateful to the team & collaborators. www.nature.com/articles/s41...
Our new study found that ancient DNA sequences in our genome, called transposable elements, can act as control hubs for leukemia stem cells, fueling therapy resistance and relapse in AML.
Led by @matlupien.bsky.social & John Dick @uhn.ca @uhnresearch.ca.
www.nature.com/articles/s41...
The first astronaut in history to speak French while en route to the moon — Canada’s very own Jeremy Hansen 🇨🇦
A new study by @uhn.ca Princess Margaret Cancer Centre and University of Oxford identified a subset of blood stem cells that are shaped by past inflammatory events. These cells can accumulate with age and are linked to mutations with a higher risk of leukemia.
www.nature.com/articles/s41...
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...
By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...
www.nature.com
This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...
