New paper! 📢
The authors used droplet microfluidics to study aryl sulfatases and their ancestors. They show higher mutation rates gave a wider distribution of active variants but fewer improved variants overall and highlight the need to test diverse mutagenesis regimes.
doi.org/10.1039/D5AN00865D
Characterizing the dynamics and functional shifts during protein evolution is essential, both for understanding protein evolution and for rationalizing efficient strategies for e.g. enzymes with desir...
