Online now: Non-genetically reprogrammed meta-neutrophils potentiate chemo-immunotherapy against lung metastatic triple-negative breast cancer
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Hao et al. develop a non-genetic reprogramming strategy using IFNγ training and Abraxane arming to create meta-neutrophils, which sustain antitumor phenotype and enable potent chemo-immunotherapy against lung metastatic triple-negative breast cancer (TNBC), overcoming cell source limitations.