🌍 Why it matters:
EV cargo is not random but structured by plasmid interactions, determining which genes enter the extracellular pool
In multi-plasmid systems, this could directly influence AMR dissemination
Would love to hear your thoughts 👇
#Plasmids #HGT #EVs #AMR
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⚙️ Mechanistically:
Mobilizable plasmids exploit conjugative transfer machinery, gain access to membrane-associated export sites, and outcompete conjugative plasmids for EV incorporation.
👉 The same interaction principle extends beyond conjugation.
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In conjugation, mobilizable plasmids exploit conjugative machinery, compete for access, and reshape transfer dynamics.
Outside of conjugation, these interactions were largely assumed to not matter for HGT.
We tested this for extracellular vesicles (EVs).
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