Excited to share the last installation of my PhD work. Worked with an all-star team on this one who really made this all come together beautifully. @ranidreamer.bsky.social @amardeeep.bsky.social @benadler.bsky.social and many others. www.cell.com/cell-reports...
@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
Looking for a POSTDOC to work on jumbo phages (those with large genomes and fascinating cell biology), using our latest ASO technology (Gerovac M et al. 2025 Nature) to define RNA export mechanisms as well as to help to advance phage therapy. Here's the job ad.
Join the Reck-Peterson lab in NYC as a HHMI Research Technician! This role will support our new work on the cell biology of secondary metabolite production in filamentous fungi. Apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Nucleus-Forming Phages: From Subcellular Organization and Viral–Host Interplay to Prospects for Phage Applications. Some new perspectives on chimalliviruses from our awesome longstanding Thai collaborators (and me). authors.elsevier.com/c/1mIJB4tPFp...
and highlight work from @jbdsf.bsky.social lab which shows similarly that the nuclear shell is not always enough on its own to protect the chimallivirus genome www.biorxiv.org/content/10.1...
Want to highlight parallel work too from @aharms485.bsky.social lab that pulled AdfM out of a phage genome screen and independently named it the same! www.biorxiv.org/content/10.1...
Bacteriophages are normally classified as either virulent or temperate. Reality is, of course, more complicated!
Here we show many bacterial isolates contain non-temperate phages that can persist through restreaking.
Thanks to all co-authors for such a great collaboration!
Morgan et al. show that a phage-encoded protein functions as an antitoxin to counter DarTG2-mediated phage defense. They further explore the interplay between this anti-defense protein, the phage nucleus replication compartment, which encloses chimallivirus genomes, and the DarTG2 phage defense system.
Jumbo phages are bacterial viruses with large genomes, oversized icosahedral capsids and complex tail architectures. Here, the authors use cryo-EM to provide a detailed structural analysis of jumbo ph...
Primary Work Address: 418 E 71st St #21, New York, NY, 10021 Current HHMI Employees, click here to apply via your Workday account. About the role: The Reck-Peterson lab studies the molecular mechanism...
[1/3] Is your favorite bacterial isolate hiding a surprise lytic virus with a VERY different lifestyle? Finally I can proudly say that our paper on persistent phages is out in Nature Microbiology. rdcu.be/eWJEp. Well done @peterdoug.bsky.social
Nature Microbiology - The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical...
Powerful and important piece by an outstanding physician, scientist, and human being @kaminskimed.bsky.social
pdf:
jeremymberg.github.io/jeremyberg.g...
jeremymberg.github.io
Jeremy Berg
My friend Naftali Kaminski is an Israeli physician, a professor at Yale, and the child of Holocaust survivors. For me he is a model of absorbing his parents' stories intensely, looking the horror of the 20th century in the eyes, and drawing the lesson of radical empathy for the suffering of others.
www.nejm.org
In the face of Israel’s ongoing assault on Gaza’s health system and the catastrophic
famine caused by the devastation, U.S. physicians have an ethical obligation to respond
and support immediate ch...
