Now published in Cell Reports! @cellpress.bsky.social
www.cell.com/cell-reports...
My postdoc Dr. Maria de la Paz Gutierrez led this work showing that cholera toxin drives epithelial L-lactate production in the small intestine, creating a nutrient that Vibrio cholerae exploits during disease
Gutierrez et al. show that cholera toxin induces epithelial LDHA-dependent L-lactate
production in the small intestine, creating a nutrient niche that Vibrio cholerae
exploits through LldD-mediated L-...
1/ Excited to share the first preprint from my lab! 🎉
My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut.
Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
www.biorxiv.org
Cholera toxin (CT) promotes Vibrio cholerae colonization by altering gut metabolism to favor pathogen growth. We have previously found that CT-induced disease leads to increased concentrations of L-la...
