Membrane Transporters, Ion Channels, Structural Biology, Bioinformatics... and other bits of fun
Purdue BS, UTSW PhD, NYUSoM PostDoc, Univ. of Oxford PI
davidbsauer.com
David B. Sauer
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The OpenBind consortium’s first release of experimental data marks a milestone in efforts to improve how artificial intelligence (AI) is used in drug discovery.
Find out more ⬇️
https://www.ox.ac.uk/news/2026-05-12-openbind-releases-first-open-dataset-and-ai-model-for-drug-discovery
Today is SLC13A5 Epilepsy International Awareness Day!
Continually impressed with all the work the TESS Research Foundation is doing to support patients and find treatments.
www.tessresearch.org
Proton-coupled alternating access in a versatile Spns drug efflux pump from Mycobacterium smegmatis https://www.biorxiv.org/content/10.64898/2026.05.09.724020v1
New publication for SLC13A5 targeting compounds! Discovery of the BI chemical probe is out now in J. Med. Chem.
Great work by Andrew Quigley, Liz Carpenter, and colleagues from Oxford's @cmd.ox.ac.uk, @boehringerglobal.bsky.social, and @thesgc.bsky.social
pubs.acs.org/doi/10.1021/...
In another case of transporters doing more than you expect: SPNS2 is a glucose importer, in addition to its S1P export activity!
Wonderful collaboration with Sarah Spiegel and colleagues at VCU School of Medicine, and the team at @cmd.ox.ac.uk
www.nature.com/articles/s41...
It's great to see this important paper by Alexander Shtyrov out. If you hadn't read it yet on @biorxivpreprint.bsky.social, you can now do so in @pnas.org. 😀
We have a late opening for postbac in my lab starting this summer. Please reshare, repost.
🔬 We’ll be at the 6th NY Area #CryoEM Meeting on May 27, presenting recent developments in #CryoSPARC for Homogeneous Ab Initio Refinement and workflows for small proteins. bit.ly/4dYMUze
We’re also proud to support the meeting as a sponsor — stop by our poster to learn more!
Structural basis for the transport mechanism and cholesterol modulation of the human proline transporter pubmed.ncbi.nlm.nih.gov/42091899/ #cryoEM
