Beautiful work from the Nemudryi lab discovering tRNA-targeting antiviral immunity in bacteria.
Shira Weingarten-Gabbay
Our work on bacterial Schlafens in phage defense is out today @natmicrobiol.nature.com!
Check out the final version here:
rdcu.be/e7Bmz
We are looking for postdocs and students to expand our team! Official postings are coming soon.
Please reach out if you're interested!
#phage #phagesky #microsky
Nature Microbiology - This study highlights that Schlafens are ancient, mechanistically conserved immune effectors that mediate antiviral immunity in organisms ranging from humans to bacteria.
First preprint from the Nemudryi Lab! 🍾
In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...
