‼️Please share‼️
Nemudryi lab is looking for postdocs to join our team and study:
🦠 Bacterial phage defense mechanisms
🧬 RNA repair & CRISPR-based RNA editing
Excited about RNA, host-virus interactions & mechanistic biology?
Let's talk!
Apply: explore.jobs.ufl.edu/en-us/job/53...
Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides.
Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
Out now–our work on bacterial cGAS-like enzymes making 2′,3′-cGAMP! Read Uday's thread for updates since the preprint including determining our lab's first protein structure and developing a new system to study bacterial STING homologs in phage defense👇
Our work on bacterial Schlafens in phage defense is out today @natmicrobiol.nature.com!
Check out the final version here:
rdcu.be/e7Bmz
We are looking for postdocs and students to expand our team! Official postings are coming soon.
Please reach out if you're interested!
#phage #phagesky #microsky
🎉Excited to share our new preprint!
TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life.
www.biorxiv.org/content/10.6...
Happy to share our latest pre-print on the Druantia defense system.
We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
A🧵
Our lab is hiring!
As our fierce technician is moving on to graduate school (GO ANNA!), we’re looking for a new tech to join our team studying bacteria-phage interactions.
Ideal for recent grads interested in molecular biology and microbiology - please reach out with a CV to [email protected].
Abstract submission is now OPEN for the 2026 Symposium on the Immune System of Bacteria!
sisb2026.rockefeller.edu
🗓 May 5–7, 2026
📍 Rockefeller University, New York City
⏰ Abstract deadline: March 16, 2026
Attendance will be capped, be sure to register early and secure your spot.
See you in NYC!
📣Huge preprint 🔔
Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.
Excited to share the first preprint from the lab! We show that ApeA defends against RNA phage infection by cleaving the phage genome:
www.biorxiv.org/content/10.6...
Nature Microbiology - This study highlights that Schlafens are ancient, mechanistically conserved immune effectors that mediate antiviral immunity in organisms ranging from humans to bacteria.
First preprint from the Nemudryi Lab! 🍾
In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
Happy to share the final version of my postdoc work on bacterial CBASS immunity with @aaronwhiteley.bsky.social published in @cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...
Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...
Tak et al. discover that bacteria use 2′,3′-cGAMP, the same signaling molecule employed
by mammalian cGAS-STING, for phage defense. In response to phage, 2′,3′-cGAMP activates
filament formation of Ca...
