Out now–our work on bacterial cGAS-like enzymes making 2′,3′-cGAMP! Read Uday's thread for updates since the preprint including determining our lab's first protein structure and developing a new system to study bacterial STING homologs in phage defense👇
Aaron Whiteley
Happy to share the final version of my postdoc work on bacterial CBASS immunity with @aaronwhiteley.bsky.social published in @cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...
Tak et al. discover that bacteria use 2′,3′-cGAMP, the same signaling molecule employed
by mammalian cGAS-STING, for phage defense. In response to phage, 2′,3′-cGAMP activates
filament formation of Ca...
