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Assistant Professor at the University of Colorado Boulder. Microbiologist. All-around nerd. http://colorado.edu/lab/aaron-whiteley/
Aaron Whiteley









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Check out this wonderful piece by @vcallier.bsky.social on how parts of the human immune system can be traced back to the conflict between bacteria and phages!
New work from Sashi Weerawarana on how TFAM compacts mitochondrial DNA 🧬 TFAM oligomerizes on DNA to form compact, homogeneous higher-order complexes (see beautiful mass photometry data below), that still retain dynamic behavior. Congratulations Sashi and Wei. www.biorxiv.org/content/10.6...
1mo
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I’m thrilled to share an update to our work on bacterial NACHT domain containing proteins! In our last preprint, we reported that bNACHT11 is activated by multiple phage proteins. We’ve now expanded this work with structural insight and investigation of programmed cell death following activation.
Bacteriophages are in a constant arms race with bacteria 🦠 The Phage ORFeome pooled library from the Aaron Whiteley lab contains phage proteins that activate antiphage defense systems — a tool to dissect the mechanisms of bacterial immunity. Aaron Whiteley
PostDoc position available! (links in post below) Feel free to share!
1mo
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2mo
Thank you to @vcallier.bsky.social and Quanta Magazine for highlighting our lab along with the incredible research from @soreklab.bsky.social @audeber.bsky.social @aaronwhiteley.bsky.social @benmorehouse.bsky.social @teralevin.bsky.social @algao.bsky.social Eugene Koonin, L. Aravind and others!
Aaron Whiteley
Karolin Luger
www.biorxiv.org
1mo
Postdoc position available in St Andrews for a structural biologist: www.vacancies.st-andrews.ac.uk/Vacancies/W/...
I'm happy to share a review that our lab put together on innate immune responses to Rickettsia. One interesting tidbit - different Rickettsia species have distinct interactions with xenophagy, where some species co-opt ubiquitylation, while others avoid it! www.sciencedirect.com/science/arti...
Excited to share our new paper: www.cell.com/cell/fulltex...
Daan C. Swarts
laurelrobbins.bsky.social
2mo
1mo
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Addgene
Use the Phage ORFeome Library to uncover the triggers responsible for immune activation.
twp.ai
Addgene: Phage ORFeome Library
BWF Announces the 2026 Investigators in the Pathogenesis of Infectious Disease www.bwfund.org/news/bwf-ann... #bwfpath
Kranzusch Lab
23d
Research Fellow - AR3262, School of Biology Salary: Grade 6 / £38,784 pa Start date: 1 July 2026 Full time Fixed term: 36 months, <p><span>Applications are sought for a committed Post-doctoral Research Fellow to work with Dr Rafael Guimaraes da Silva conducting research for a Leverhulme Trust Research Grant funded project to dissect catalysis and allostery in a gut microbiome ATP phosphoribosyltransferase enzyme.&nbsp; The primary duties will be to uncover the catalytic and allosteric mechanisms via protein crystallography and enzymology.</span></p> <p><span>The successful applicant will have (or be near to completion of) a PhD in Biochemistry or Structural Biology with expertise in X-ray crystallography and enzymology.&nbsp;</span></p> <p><span>The post is available for 36 months starting 1<sup>st</sup> July 2026 or as soon as possible thereafter. </span></p> <p><span>Further information and informal enquiries may be directed to Dr Rafael Guimaraes da Silva at&nbsp;</span>[email protected]</p> <p>&nbsp;</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Benefits:</strong></p> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;">&nbsp; &nbsp; &nbsp; &nbsp;</span><span>Financial contribution to&nbsp;</span><a href="https://www.st-andrews.ac.uk/hr/payandpensions/removalandrelocationpolicy/" style="color: #565661; background-color: transparent;">relocation</a>&nbsp;<span>(subject to eligibility)</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;">&nbsp; &nbsp; &nbsp; &nbsp;</span><span>Membership of the USS Pension Scheme with generous employer contributions of 14.5%</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;">&nbsp; &nbsp; &nbsp; &nbsp;</span><span>A hybrid working environment, including partial homeworking where appropriate and a range of family friendly policies, supporting work-life balance</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;">&nbsp; &nbsp; &nbsp; &nbsp;</span><span>Staff discount scheme for local and national goods and services</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;">&nbsp; &nbsp; &nbsp; &nbsp;</span><span>Free staff parking, employee Carshare and Cycle to Work Schemes and subsidised local bus travel</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;">&nbsp; &nbsp; &nbsp; &nbsp;</span><span>Subsidised sports membership, reduced tuition fees on degree programmes for staff, access to training and development opportunities including LinkedIn Learning, access to library facilities, salary sacrifice scheme</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;">&nbsp; &nbsp; &nbsp; &nbsp;</span><span>34 Days Annual Leave plus 5 Public Holidays.</span></li> </ul> <p><span><br> </span></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><em>At St Andrews, equality, diversity, and inclusion are central to who we are and form a core pillar of our University Strategy. We are committed to creating a fair, inclusive and supportive workplace, reflected in our participation in national diversity charters and awards, including Athena Swan, Carer Positive and the Race Equality Charter.&nbsp;</em></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><em>We particularly welcome applications from people from Black, Asian, minority ethnic and minority religions backgrounds and from LGBTQ+ and disabled people.&nbsp;</em></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">&nbsp;</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Closing date: 17 April 2026</strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Interview date: 11 May 2026</strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Job Description:&nbsp;<a href="https://www.vacancies.st-andrews.ac.uk//ViewAttachment.aspx?enc=jmxpV+AcVus8i/wvT3FZXrrCOvCUGNWd9uca/tGZrAJOxn0uaIw998B27m1Z2faQPrIL0fNvKayeQQ9Vm6dRjh8e9IpvpaUCTN3uAzHFqby4lpmr7kDQu7hbKVYB1s1b" target="_blank" title="AR3262RS FPs.pdf">AR3262RS FPs.pdf</a><br> </strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Ref no: AR3262RS</strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>&nbsp;</strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">School of Biology</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">Salary: Grade 6 / &pound;38,784 pa</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">Start date: 1 July 2026</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">Full time</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">Fixed term: 36 months</p>, Working Hours : Full Time School/Unit : School of Biology Job Family : Academic (Research) ,
www.vacancies.st-andrews.ac.uk
Research Fellow - AR3262
DURHAM, N.C. – The Burroughs Wellcome Fund is pleased to announce the recipients of the 2026 Investigators in the Pathogenesis of Infectious Disease (PATH) awards, recognizing assistant…
www.bwfund.org
Malcolm White
BWF Announces the 2026 Investigators in the Pathogenesis of Infectious Disease - Burroughs Wellcome Fund
Thomas P200 Burke
Over 10 species of Rickettsia cause serious human disease across the globe, including deadly spotted fever and typhus. These arthropod-borne microbes …
www.sciencedirect.com
Innate immune responses to Rickettsia: emerging themes and contrasts between species
Over two billion years, a fierce battle has raged between bacteria and the viruses that infect them. The resulting evolution has shaped the way our bodies fight disease today. @vcallier.bsky.social reports: www.quantamagazine.org/the-ancient-...
Zhu Lab at Vanderbilt University Medical Center
1mo
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
Burroughs Wellcome Fund
Over two billion years, a fierce battle has raged between bacteria and the viruses that infect them. The resulting evolution has shaped the way our bodies fight disease today. @vcallier.bsky.social reports: www.quantamagazine.org/the-ancient-...
1mo
Quanta Magazine
Quanta Magazine