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1/n What fraction of the human genome is essential for cells? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay.bsky.social @jshendure.bsky.social www.biorxiv.org/content/10.6...
1/ Preprint alert 🚨🚨🚨 How do cells decide where an mRNA should end? And how is that decision coordinated with splicing and transcription while the RNA is still being made? Here's what first author @hopem105.bsky.social found 👇
Loss is maintenance DNA methylation during cell proliferation/aging etc is not random. Intriguing new findings from the Rao lab show a strong correlation with dinucleotides flanking CpG sites. Seems likely to be important. www.biorxiv.org/content/10.6...
PREPRINT ALERT🚨➡️Genetics influencing #epigenetics: Flanking DNA sequences influence #DNAmethylation maintenance 🧬 It’s been a minute because I needed a media break 🧘🏻‍♂️, but I couldn’t resist popping back for this: We just dropped a new #bioRxiv preprint 😃🤞🏻 BTW I’m looking for (academic) jobs
Flanking DNA sequences determine DNA methylation maintenance in proliferation, cancer and aging https://www.biorxiv.org/content/10.64898/2026.04.09.717557v1