The in vivo model supported this axis as well: in EL4 lymphoma-bearing mice, antibiotic treatment preserved near-normal filaggrin in tumour-adjacent epidermis. Together, the data support microbial-immune crosstalk as a mechanistic contributor to CTCL skin barrier pathology.
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This work was spearheaded by Maria Gluud and the team at Skin Inflammation & Cancer @niels-odum.bsky.social at @sic-ucph.bsky.social and our fantastic collaborators!
Finally, this study would not have been possible without the support from LEO Foundation, DFF, @cancer.dk @novo-nordisk.bsky.social