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1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by @eduxbury.bsky.social with @alicegodden.bsky.social @immler.bsky.social Johnny de Coriolis Hanne Carlsson www.biorxiv.org/content/10.6...
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Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine ...
www.biorxiv.org
Lifespan-extending downregulation of insulin signalling reduces germline mutation load
Alexei Maklakov