Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
Alexei Maklakov
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Book review 📚 How long can humans live? We simply don’t know
go.nature.com/3QelWur
An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan
Great first post by @itamarh.bsky.social 😀
Very happy to contribute to this cool study!
🚀 The new edition of Beyond Beginner R course is now underway. A few improvements this time:
- @philipleftwich.bsky.social & @eivimeycook.bsky.social l as instructors
-More R reproducibility examples
- Quarto workflows
- Handling large datasets
- Integration of AI tools
shorturl.at/R97jw
Job advert!
There is microbiology lectureship at @biouea.bsky.social with a focus on non-academic impact:
vacancies.uea.ac.uk/vacancies/20...
New preprint from my PhD is out!
We show that loss of miR‑219 disrupts neural border gene programs and prevents neural crest specification.
Excited to finally share it 🚀
www.biorxiv.org/content/10.6...
#xenopus #miRNA #genomics
"Unlike my good friends Dobzhansky and Simpson, I did not think that the only role I could take in a society was that of president."
Ernst Mayr on why he became the first editor of Evolution.
And the press release is at www.su.se/english/news...
Sad to hear of the passing of Robert Ricklefs - a giant of Ecology who simultaneously pushed forward big ideas at multiple biological levels yet took time for detailed natural history .. McGill does a nice job summarizing his impressive contributions 🌐🧪 dynamicecology.wordpress.com/2026/06/11/r...
We took ~750,000 whole genomes and found the putative mechanism by which mitochondrial DNA mutations accumulate with age in blood. Spoiler: we think these mutations arise by replication error and tag age-related clonal hematopoiesis. Read @nature.com broad.io/ob2jft
Longer human lives may be making an old evolutionary pattern harder to ignore. Late-acting harmful variants and youth-tuned pathways can now shape health on a scale selection never removed. doi.org/hb7fmz
Robert Ricklefs, a giant of ecology, passed away on Sunday. It is hard to overstate the extensive impact Bob had on the field. He was elected a member of the National Academy of Sciences in the US,…
Genome-wide analyses indicate that accumulation of mitochondrial DNA mutations, a hallmark of ageing, may be caused by cryptic replication errors, which act as passenger mutations that eventually become detectable with age owing to age-related somatic mosaicism, rather than oxidative damage.
View details and apply for this Impact Lecturer in Microbiology (ATR1737) vacancy in University of East Anglia. Faculty of Science
School of Biological Sciences
Impact Lecturer in Microbiology...
Neural crest (NC) multipotent stem cells give rise to many tissues including most of the peripheral nervous system, pigment cells and the craniofacial mesenchyme and skeleton. During gastrulation and ...
1/6) What if aging begins, in part, as a bargain made in youth? In turquoise killifish, editing vgll3—a gene linked to puberty-timing in humans and salmon—revealed one of the first causal single-gene examples of antagonistic pleiotropy in vertebrate aging 🧵
A review article now published in Nature Reviews Genetics brings together evolutionary theory, comparative genomics and large-scale human genetics to explain why we age and why aging rates differ among individuals and species.
It turns out all that screen time disrupts brain development...in guppies. Now out @royalsocietypublishing.org royalsocietypublishing.org/rsbl/article....
