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PhD Student at Helmholtz AI | MemBrain analysis for Cryo-ET #teamTomo

Lorenz Lamm

The #ChlamyDataset is on the cover of @cp-molcell.bsky.social 🖼️🥰! Read @lifeonthewedge.bsky.social's great thread🧵 for the inside scoop🍨 on all the #TeamTomo developments already made possible since these 1829 tomos hit EMPIAR 🧪 🧶🧬 For more, here's the old preprint thread: bsky.app/profile/cell...

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines. 🧵👇 doi.org/10.1002/pro.70578

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Are you also often frustrated when DINOv2 puts very high attention on background patches, rather than cute fox heads? @virtualhomo.bsky.social found an elegant way to regularize DINOv2 training using randomised linear algebra 🤯 Check out his thread or even his poster if you're at #NeurIPS2025.

In case you're missing my poster at #NeurIPS2025 about how I fine-tuned DINOv2 to ophthalmological images, here are some animations so you don't miss out! 🔗 Preprint: doi.org/10.48550/arX... 🔗 Code: github.com/peng-lab/rmlp 🧵1/9

I wrote a paper with @lorenzlamm.bsky.social, @marionjasnin.bsky.social, @tingyingpeng.bsky.social, F. Eckardt and B. Schworm and got accepted at #NeurIPS2025 and fun fact: 90% of viewers are enby vegans! 🤟 So if u fit there, u might wanna check it out! Maybe also if you don't. We're allies here <3

Online Now: Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii Online now:

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This one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]

Ben Engel

James Barrett

Vision Transformers (ViTs), such as DINOv2, achieve strong performance across domains but often repurpose low-informative patch tokens in ways that reduce the interpretability of attention and feature...

arxiv.org

Randomized-MLP Regularization Improves Domain Adaptation and Interpretability in DINOv2

Using the latest advances in instrumentation and computational workflows, Kelley et al. present a large-scale annotated cryo-electron tomography dataset of the model green alga, Chlamydomonas reinhardtii. This unprecedented community resource is rich in high-resolution biological information and empowers the development of new methods for visual proteomics.

dlvr.it

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Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii