Associate Professor in Bioengineering 🇮🇹@ Linköping University 🇸🇪
Bioengineering/Genomics/Development/3R/Teeth/HeavyMetal/Photography
Pierfrancesco Pagella
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ICYMI from @cami-autorino.bsky.social & @nicolettapetridou.bsky.social 🐟
An initial idea from our previous work turned into 💣💥🔥🔥🔥: Pioneering activity of WNT-beta catenin - here, we said it: look at the preprint and let us know your thoughts!!
Led by Tamina Weiss, @annanordin.bsky.social , @claudiocantu81.bsky.social at @liu.se
How do pairs of DNA loci - such as enhancers and promoters - find each other inside the nucleus? 🤔
Most models assume the random forces driving locus motion are independent in space
New preprint by
@janniharju.bsky.social: this assumption fails in living cells 🧵
www.biorxiv.org/content/10.6...
Congratulations @ivaskalab.bsky.social team for this study on the role of vibration in vocal cord cancer! Was a fun collaboration 🎤🎤
Register to The PALS Summer School in TranscriptOMICS
👉 Before April 15
And Learn how to perform:
Single-cell Multiome data analysis and integration — workflow management and reproducibility
from Daniel Mouzo @qmul.bsky.social
@scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social
⚡ Our paper is now out in @natphys.nature.com !
This version now includes a detailed molecular characterisation of the optogenetic perturbations, new insights on the relevance of tricellular junctions for tissue morphology, and beautiful light-sheet timelapses. 🔬
www.nature.com/articles/s41...
Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪
To learn about
➡️ Transposable elements and the human brain ⬅️
by ⭐ professor Vivien Horvath⭐ from @umeauniversitet.bsky.social
@kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social
REGISTER NOW!
www.trippus.net/summerschool...
Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪
To learn about
➡️ Dynamics of immunological tissue architecture in the human gut ⬅️
by ⭐ professor Simon Koplev ⭐ from KTH @scilifelab.se
@kawresearch.bsky.social @remeseiro-lab.bsky.social
REGISTER NOW!
www.trippus.net/summerschool...
‘Astrocytes connect specific brain regions through plastic networks’
Really cool @nature.com study by @melcooperphd.bsky.social
@liddelowsa.bsky.social and colleagues
🧪🧠
www.nature.com/articles/s41...
Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...
Video
Pierfrancesco Pagella
Zebrafish Rock!
Tissue phase transitions are key to morphogenesis. Now adhesion-driven rigidification is identified as key to epithelial organization but only if uncoupled from density-driven jamming.
Register to The PALS Summer School in TranscriptOMICS
👉 Before April 15
And learn to
Integrate Chromatin Accessibility w 3D Genomics
w hands-on session by Luminita Ruje from @mrc-lms.bsky.social
@scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social
www.trippus.net/summerschool...
Igor Adameyko
☕ @nicolettapetridou.bsky.social & co report a feedback loop between Nodal signaling and tissue phase transitions in zebrafish #embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which limits its diffusion and speeds up Lefty expression.
go.nature.com/4vgBYmo
What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!
www.nature.com/articles/s41...
In development, cells navigate highly complex gene-regulatory landscapes to make fate
choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity,
and collective multi...
🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social !
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS
To learn
Enhancer dynamics in living Drosophila embryos
by ⭐ prof Takashi Fukaya⭐ @fukayalab.bsky.social
@utokyoofficial.bsky.social
@kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social
REGISTER
www.trippus.net/summerschool...
Join The Summer School in Transcriptomics 🧬
Deadline on April 15!
We cannot wait to host you in beautiful Swedish Summer 🇸🇪🌞
@remeseiro-lab.bsky.social
@scilifelab.se
@kawresearch.bsky.social
@liu.se
@umeauniversitet.bsky.social
www.trippus.net/summerschool...
FASTEN YOUR SEATBELTS:
Tamina Weiss, inspired by previous data from @ppagella86.bsky.social
found that beta-catenin is more than an adaptor protein downstream of #WNT
It is an orchestrator that scouts and opens enhancers for transcriptional activation
@biorxivpreprint.bsky.social
Autorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...
go.nature.com
Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.
Register to The PALS Summer School in TranscriptOMICS
👉 Before April 15
And learn:
Non-coding variants Prioritization based on 3D genomics
epigenomics & advanced Transcription Factor analysis with AI
by Dr. Artemy Zhigulev @ki.se
@scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social
Enhancer pioneering activity of Wnt/β-catenin signaling https://www.biorxiv.org/content/10.64898/2026.06.12.731851v1
