STOP using ipTM for #AlphaFold PPI screens.
* Artificially LOW when both full-length proteins have irrelevant, non-binding IDRs/domains.
* If one protein is folded & other contains irrelevant IDRs or domains, the score is too HIGH bc of d0.
* Use ipSAE or LIS.
www.biorxiv.org/content/10.1...
