Even more exciting, we find that other AML drivers—like NUP98 and KMT2A fusions—coerce their own “majestic creatures” into the same C-body nightmare, revealing a shared structural logic behind clinically similar leukemias. See the original thread ⬇️ for more insights.
Peggy Goodell
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
