And here’s the twist we uncover in the new work ⬇️: the gremlin’s power was never in the cytoplasm at all. NPM1c must act *in the nucleus* through phase separation, bringing together multiple proteins on chromatin to drive AML... Overturning years of assumptions.
Mutant NPM1 and various leukemia oncofusions form biophysically indistingishable nuclear
condensates, termed C-bodies, which orchestrate leukemogenic gene expression. These
findings consolidate divers...
