Original work here ⬇️, led by the inimitable Lorenzo Brunetti and Michael Gundry. This work became foundational in the field.
Brunetti et al. show that specific loss of NPM1c from the cytoplasm leads to downregulation
of HOX genes and differentiation in NPM1 mutant AML. Blocking NPM1c nuclear export
by XPO1 inhibition reduce...
