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Mucosal Immunology & Anti-Tumor Immunity Postdoc | Wendy Garrett Lab | Harvard School of Public Health
Slater Clay
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So good to see this finally out!
17d
Delighted to share our latest paper out today - led by @ardeena-berisha.bsky.social - we show that we can boost the anti-cancer activity of human MAIT cells by getting them to use lactate & also directing them using bi-specific engagers as a proof of concept academic.oup.com/jimmunol/art...
🚨 New Publication Alert - out now in @science.org - We outline the environmental regulators of MAIT cells including the nutrients they need - with them coming into focus in cancer this is sure to be important - read it here doi.org/10.1126/scis...
1mo
10d
Slater Clay
Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation www.science.org/doi/10.1126/... @science.org @thedohertyinst.bsky.social @hay-mish.bsky.social
6mo
Andy Hogan
Andy Hogan
Waggoner Lab
Nutrients are important environmental factors that affect the functional responses of MAIT cells to challenge.
doi.org
Environmental regulation of mucosal-associated invariant T cells: Adding food for thought
Online now: Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit
17d
Immunity
Abstract. Mucosal-associated invariant T (MAIT) cells are unconventional T cells, which upon activation can display potent cytotoxic and cytokine-producing
academic.oup.com
Lactate conditioning reprograms mucosal-associated invariant T cell metabolism boosting effector function
Lobel, Fonseca-Pereira, et al. demonstrate that dietary sulfur amino acids (Saa) enhance anti-tumor immunity in colon cancer. A high-Saa diet expands the bacterium Mucispirillum schaedleri, which activates a natural killer T cell-dendritic cell axis to restrict tumor growth, illustrating how nutritional interventions can be leveraged for cancer immunotherapy.
dlvr.it
Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit