We attribute this to the gauche preference of O–C–C–O dihedrals, which drives oligoethers to bring reactive groups together.
The key finding: very simple oligoether tethers could be powerful scaffolds for highly active bifunctional catalysts.
Philip
Consider submitting your peptide research to a special joint issue of JOC and Biochemistry on the Chemistry and Biology of Peptides!
axial.acs.org/biology-and-...
We built some open source photo reactors and implemented them into the organic teaching lab here at Bradley. This was a fun project led mainly by the undergraduate students! Check it out: pubs.acs.org/doi/10.1021/...
I received many requests to share materials from our undergraduate course “Machine Learning in Chemistry”
— here you go!
A preprint summarizing insights and lessons learned:
chemrxiv.org/engage/chemr...
A Jupyter Notebook Tutorial Gallery:
xuhuihuang.github.io/mlchem/html/...
Check out our review on DNA-scaffolded catalysis! This link provides free full text access until the end of 2025: authors.elsevier.com/a/1m43W9CpcY.... Big thanks to co-authors @edwardpimentel.bsky.social , Ashley Ogorek, @ethan-hartman-125.bsky.social , and Caleb Cox
It's an honor to be a part of this cohort! I am extremely thankful that the ACS is willing to sponsor young scientists during these uncertain times.
I had the privilege of reading many early drafts of this work. Since the beginning the conclusion that we're potentially missing significant structural information using routine characterization methods has fascinated me. Great job, Brenna!
Catalysts with simple oligoether linkers significantly outperformed polymethylene-tethered ones, and matched a far more complex peptide foldamer catalyst with preorganized reactive groups.
My second-to-last PhD paper is out in JOC, and it's one of my favorites!
We looked at how flexible tether composition affects bifunctional catalysis. 🧵 #Chemsky #Catalysis
doi.org/10.1021/acs....
In honor of the greatest 3-9 team of all time, your 2021 Nebraska Cornhuskers. My first year cheering for the huskers, filled with magical sicko disaster football. I saw things happen I didn't even know were possible. GBR!
@sickoscommittee.org
@edsbs.bsky.social
@brennabierman.bsky.social
