It’s great to see this story out. Congratulations!
Alper Akay
Thrilled to share our new Brockdorff lab paper at NSMB: we show that the primary role of m6A RNA modification on Xist is to promote RNA degradation. Xist turnover is mediated by the NEXT complex, not PAXT, and is independent of the m6A reader YTHDC1. www.nature.com/articles/s41...
Wei et al. show that the primary function of m6A on the nuclear long noncoding RNA Xist, a master regulator of X inactivation, is to promote RNA degradation. Xist turnover is mediated by the nuclear e...
