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@drsusanna.bsky.social paper is now out in its final form. Relative to the original preprint, we now show additional mutant data and a better way to display heat maps of gene activation. www.cell.com/current-biol...
Be on the lookout for an exciting meeting that Matilde @matildegalli.bsky.social , Silvia @santoslab.bsky.social and I are organizing next year in Amsterdam. It will be a lot of fun. coming-soon.embo.org/w27-24
Nice new paper from Stas Shvartsman's group presenting an elegant mathematical model for the control of metamorphosis and testing it using Erk optogenetics. www.pnas.org/doi/10.1073/...
Happy to have contributed, together with former student Yitong Xu, to this paper. Read the thread below from @brugueslab.bsky.social for more details.
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
Congrats, Ale and lab. A big step forward with a lot of new and unexpected observations! These waves are fascinating indeed
Advanced grad students + postdocs: apply for the 2026 #kitpqbio summer course, "Physical Principles of Morphogenesis in Plants and Animals," at buff.ly/OXXMKEv. Apply by Feb. 1. Course directors Adrienne Roeder (Cornell) and Sebastian Streichan (UCSB)
@sushantbangru.bsky.social and @rdiegmiller.bsky.social new review on regeneration is out in Nature Reviews Molecular Cell Biology. A fun piece to write and another great collaboration with @kenposs.bsky.social.
We are hiring!
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Using quantitative live imaging, Brantley et al. reveal that cells decode dynamic BMP signaling during dorsal patterning of the Drosophila embryo by integrating activity over time. These results advan...
www.cell.com
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coming-soon.embo.org
System identification approaches are commonly used in engineering to infer simple yet predictive models of complex systems from their responses to ...
Rapid transcriptional response to a dynamic morphogen by time integration
Cycling towards fate: cell-cycle control in development
Optogenetic control of transition to metamorphosis | PNAS
www.pnas.org
Stefano Di Talia
Stefano Di Talia
Stefano Di Talia
Stefano Di Talia
Stefano Di Talia
Stefano Di Talia
Stefano Di Talia
Kavli Institute for Theoretical Physics
Brugues Lab
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
New Online! Signal control during tissue regeneration in adult animals
Please repost!!: We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!! www.nature.com/naturecareer...
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Signal control during tissue regeneration in adult animals
Nature Reviews Molecular Cell Biology, Published online: 11 November 2025; doi:10.1038/s41580-025-00917-1The ability to track single cells in vivo, combined with insights into chromatin structure, immune–tissue crosstalk, bioelectric and metabolic cues and quantitative modelling, is changing our understanding of how tissues are repaired and renewed. This Review discusses how signals are regulated during regeneration and future directions for a more quantitative understanding of regenerative biology.
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Tenure-Track Assistant Professor Position –AI/ML for Cell Biology
www.nature.com
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology - Durham, North Carolina (US) job with Duke University School of Medicine | 12844591
Brugues Lab
Alessandro De Simone
Nature Reviews Molecular Cell Biology
Scott Soderling