A fascinating thread highlighting compelling investigations of the effects (or lack thereof) of distal vs proximal enhancer activation of promoters.
The ability for elements to promote transcription from megabases away has always astounded me. Excellent work - with clearly more to do!
Anthony Dornan
Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/
www.biorxiv.org/content/10.6...
