🚨 New @biorxivpreprint! 🧬💻
Can the spatial architecture of chromatin predict chemoresponse?
We integrated FLIM imaging + ML to show that spatially organized "open" chromatin states in pre-treatment biopsies predict resistance in TNBC.
www.biorxiv.org/content/10.6...
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Key findings:
1️⃣ Beyond Bulk: Single-nuclei distributions, not bulk averages, drive prediction.
2️⃣ Spatial Topology: GNNs reveal where these nuclei matter.
3️⃣ Chromatin Memory: This signature persists post-treatment - an intrinsic property of the resistant ecosystem.
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