This has been a long journey and it's exiting to see our story about the Atg2-18 lipid transfer complex, headed by Sabrina Chumpen, published in @embojournal.org!
Great teamwork of the labs @arnemoeller.bsky.social, Stefano Vanni, Fulvio Reggiori and Christian Ungermann!
#cryoEM #autophagy #membrane
Dmitry Shvarev
Atg18 interaction positions Atg2 for efficient lipid transfer into phagophore elongation
Sabrina Chumpen Ramirez, @dmitryshvarev.bsky.social et al
link.springer.com/article/10.1...
During macroautophagy, the de novo formation of the autophagosome at a membrane contact site (MCS) with the endoplasmic reticulum requires directional lipid flux for the growth of the initial phagopho...
