Aging lab @Stanford. Our interests include mechanisms of aging, brain aging and rejuvenation, neural stem cell aging, genetics of lifespan and suspended animation in killifish
BrunetLab
Thrilled to see this out today in PLOS Biology. With postdocs Siqi Liu and Flávio Costa, we ask why the gut microbiome loses its balance with age. It's an Unsolved Mystery piece: a framework, not a finalized account, with predictions we lay out for the field to test. 🧵
Interested in aging and rejuvenation?
We have a new Research Assistant position to understand aging at the cellular level!!
Come join our team!!! 😎
careersearch.stanford.edu/jobs/life-sc...
Why do guinea pigs have so many natural bypass arteries — and mice and humans almost none?
We develop in vivo Perturb-seq for endothelial cells to ask how protective collateral arteries are built.
Preprint with by Irene Fan, Ronghao Zhou, and Kristy Red-Horse:
www.biorxiv.org/content/10.6...
Excited to share a pre-print from a collaboration between my lab at NIH, Len Petrucelli's lab at University of Miami, and Shyamal Mosalaganti's lab at University of Michigan.
"Then, in 2021, the Princeton University geneticist Coleen Murphy found that Caenorhabditis elegans worms could learn to avoid a pathogenic bacterium by eating, or even just swimming around in, pureed worms who had learned the hard way."
www.quantamagazine.org/are-memories...
Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social
doi.org/10.1038/s435...
Planning a Perturb-seq experiment? Building virtual cells?
First step to good models is good data. How many cells to profile? How deeply to sequence? What statistical power?
Check out PerturbPlan — new tool from Ziang Niu in Katsevich Lab
www.perturbplan.com
www.biorxiv.org/content/10.6...
Have you ever wondered why mice do what they do when they are free to do whatever they want? Check out our latest (and this slightly delayed thread about our recent paper, led by Caleb Weinreb and friends...) www.cell.com/neuron/fullt...
In the 1960s, worm-training experiments and their strange implications captivated the nation. Columnist Claire L. Evans follows the neuroscientists who attempted to recapture the magic.
Aging may feel gradual… but what if it’s not?
In our recent paper, we tracked fish continuously from puberty until death.
This gave us a unique view of how aging unfolds across the adult lifespan.
🧵
Dario Riccardo Valenzano
BrunetLab
Jesse Engreitz
www.biorxiv.org
Michael Ward
Éthyliszt, Esq.
Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...
www.science.org
Datta Lab
Claire Bedbrook
To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...
Host-associated microbiomes are stable across most of the lifespan, but what drives late-life deterioration remains unclear. @dvalenzano.bsky.social &co propose interventions that restore #immune surveillance capacity alongside ecologically informed #microbiome management.
🧪 #aging
PLOS Biology
Weinreb et al. reveal a hierarchy of timescales in mouse behavior, including low-level
syllables and high-level behavioral states. States and syllables are encoded in different
brain areas. Prefrontal...
Stanford University is seeking a Life Science Research Professional 1 to study the mechanisms of aging and rejuvenation, particularly in a variety of....
Host-associated microbiomes are stable across most of the lifespan, but what drives late-life deterioration remains unclear. This Unsolved Mystery proposes interventions that restore immune…
