How do sperm and egg fuse? Surprisingly, we still don’t fully know…
Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together.
We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion.
tinyurl.com/34cm4xat
Read on! 🧵👇
Video
1/ 🚀 Excited to release: napari-mcp - agentic control of napari from any MCP-capable AI assistant!
Use it for interactive image processing, analysis, and visualisation! Really cool project from @ilan-theodoro.bsky.social from my team!
#napari #bioimageanalysis #MCP @biohub
🐟!JOB ALERT!Duke, Durham, NC!🐟 We are looking for a research tech (our current tech is starting grad school this Fall (Yay!)). The candidate will contribute to our ongoing research projects on tissue morphogenesis using zebrafish. Please RT🙏
www.munjallab.com/join-us
Amazing work by amazing colleagues!
New piece on the mechanics of squamous epithelial shape transition highlighting the role of tensile forces, force transmission by Dumpy & elastic resistance by the ECM in the developing wing. Terrific work from Stefan Harmansa @morphomechanics.bsky.social with Alex Erlich🍾👏:
tinyurl.com/2p58b3w3
Briefly, after organ injury, 100 milliseconds, we detected collective changes in membrane potential at the tissue level. This is so far the earliest detected wound-response!! This electric signal sparks the formation of a tissue-wide calcium wave👇
I’m thrilled to share the first preprint from the Piacentino Lab @hopkinsmedicine.bsky.social! We show that developing inner ear requires a secreted lipid chaperone, APOD, working in a positive feedback loop to amplify FGF/MAPK signaling. 👂 #DevBio Check it out! www.biorxiv.org/content/10.6...
www.munjallab.com
Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2
The formation of cranial placodes requires groups of ectodermal cells to interpret inductive signals in a robust and organized manner, yet how signaling responses are coordinated across a developing f...
Hosting my PhD mentor, @thomaslecuit.bsky.social was a welcome reminder of how fortunate I am to do what I do. It was a privilege to host him at Duke and reflect on what good mentorship can build. Thank you for coming, sharing your inspiring science, and for your unwavering support.
Rita Mateus
Mike Piacentino
Zebrafish Rock!
Akankshi Munjal
Wonderful to be part of exciting Program at Harvard University & CMSA, Mathematics &Biology: Morphometry, Morphogenesis and Mathematics. Thank you 🙏🏼 and congrats to organizers for their invitation. Great to see and discuss with wonderful colleagues, not least @akankshi.bsky.social! 🤩
Thomas Lecuit
Visiting Duke Univ. yesterday. What a treat to be hosted by @akankshi.bsky.social Munjal (former PhD std) 🤩 and spending time with fantastic trainees & wonderful faculty, such as
Stefano di Talia @ditalialab.bsky.social. Many thanks for the invitation 🙏🏼. A place full of talent & energy.
Thomas Lecuit
Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.
Video
Yarui Diao
Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf
Trimodal single-cell analysis reveals gene-regulatory architecture in complex tissues.
